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In design and conduct of the trial, authors contributed particular expertise in: RCT design, management and analysis (DK, NW, GL, TP, SG, DT); primary care (DK, JC, CC-G, UM); psychiatry (GL, CD, IA, SG); psychopharmacology (SD, IA); statistics (TP, NW); qualitative methods (CC-G, UM); and health economics (WH).

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Mirtazapine has a rapid onset of activity in comparison to many anti-depressant medications.

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CNS depressants, decarboxylase inhibitors (such as carbidopa and benserazide), diltiazem, drugs that lower seizure threshold, growth hormones, hormonal agents, lithium carbonate, losartan, methamphetamine, metoclopramide, painkillers, sedatives, serotonin receptor antagonists (such as methysergide, nefazodone, cyproheptadine, and ritanserin), or thyroid hormones.

It is also sometimes used as a sleep aid because of its sedating effect but this use is not recommended.

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To complicate the matter further, RU486 administration in humans induces elevation of cortisol levels, possibly by blocking GR-mediated negative feedback (), and therefore it is difficult to dissect, once again, whether the clinical effects of RU486 are mediated by blocking or rather by facilitating GR signalling.

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